Article Brief Summary:
A great article showing that central lines are not needed on every sepsis patient.
Covered excellently on EMCrit.
highlights:
300 patients, randomized to standard EGDT with SVO2 goals, and lactate clearance group (looking for greater than 10% clearance). no blinding (still they all had central lines, but for the lactate group it was not connected to the analyzer)
groups looked similar and needed similar treatments to reach endpoints: avg 4.5L fluids, 75% pressors, 25% intubated. few needed PRBC's