Toxicology and Pharmacology

Critical Care Pharmacology

Presentation Summary: 
Review of CC pharm

Handouts from Pharmacy

Presentation Summary: 
Handouts from Breakout session during airway lab

ACMT position Statement: Interim guidelines for the use of lipid resuscitation therapy

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Journal Name: 
J Toxicol Clin Toxicol
Article Brief Summary: 

Some brief guidelines on the proper use of lipid therapy:
1.5 ml/kg of 20% lipid emulsion IV over 2-3 min ( a litte bit slower than previous recs)
can repeat bolus in asystole and in those who initially improve but deteriorate later after being placed on infusion
0.25mg/kg/min infusion, can incraese if pt starts getting worse
should terminate after 1 hour unless pt still unstable
max dose not see in these guidelines but have seen it before: 8 mg/kg

R3 Case Conference - Etomidate, Friend or Foe

Presentation Summary: 
Review of Etomidate

Deep Sedation

Presentation Summary: 
Review of Sedation principles and anesthetic agents and techniques

Giving new meaning to "Bed, Bath and Beyond"

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Journal Name: 
Emergency Medicine News
Article Brief Summary: 

Nice non-academic review of bath salts.
still sort of legal although regulations are starting.
Most samples tested are derivatives of pyrovalerone -a sympathomimetic agent
Hallucinations and agitation are mostly the symptoms to look for, and symptoms can last. Aggressive and suicidal behavior have been associated with its use.
Treat symptomatically.
try to get testing done, and call PCC, so we can track this new"poor man's meth"  

Street drug alert: dewormer in cocaine; anthrax in heroin

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Journal Name: 
Emergency Medicine News
Article Brief Summary: 

We have started seeing these- patients with neutropenia, also patients with ulcerated lesions, especially to the face. Ask about cocaine use!
This is the cocaine tainted with levamisole, a veterinary dewormer. Up to 70% of the cocaine seized by the DEA contains levamisole.
NEJM has cool and impressive case of vasculitis on its images in Medicine section.
Call the PCC!!!

Opioid safety in patients with renal or hepatic dysfunction

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Journal Name: 
Pain Treatment topics
Article Brief Summary: 

We were talking about this the other day...My notes relate to the renal failure part of the article!!
My take. Nothing is super safe:

Hyperkalemia in acute digitalis poisoning: prognostic significance and therapeutic implications

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Journal Name: 
Clinical Toxicology
Article Brief Summary: 

The best article showing the prognostic significance of hyperkalemia.
My nuggets from it:
1. hyperkalemia >5.5 meant certain death unless you treat with antidote
2. treatment of hyperkalemia with methods that alkalinize the serum, force K movement into the cell, or force the elimination of K don't make sense in these cases. Hyperkalemia here is just a measure of Na/K ATPase poisoning by digitalis glycosides.
3. Hyperkalemia was better prognostic marker for mortality than either ECG and digoxin level.

Bread and Butter Toxicology

Presentation Summary: 
A good review of toxicology.