Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
(1 vote)
Landmark Article?:
Yes
Journal Name:
The New England Journal of Medicine
Year Published:
2001
Article Keywords:
sepsis, septic shock, Manny Rivers, early goal directed therapy, fluid resuscitation, central venous pressure, central venous oxygenation, pressors
Article Brief Summary:
The article that formed the foundation behind early goal directed therapy where we now initiate aggressive fluid resuscitation in the ED, measure SVO2 as a measure of resuscitation, and start pressors early to support blood pressure. This articles showed that such aggressive measures were key to improving outcomes in patients with severe sepsis and septic shock.