A great article showing that central lines are not needed on every sepsis patient.
Covered excellently on EMCrit.
highlights:
300 patients, randomized to standard EGDT with SVO2 goals, and lactate clearance group (looking for greater than 10% clearance). no blinding (still they all had central lines, but for the lactate group it was not connected to the analyzer)
groups looked similar and needed similar treatments to reach endpoints: avg 4.5L fluids, 75% pressors, 25% intubated. few needed PRBC's 
mortality 20% overall  - no difference in this between groups, similar LOS, similar complications
issues (maybe only potential): 152 patients excluded; not blinded
sooo.. lactate is great surrogate if you don't want to deal with SVO2 catheters and pt ooks fine so you feel about having to put a central line just for EGDT.